A thrombopoietin receptor agonist; induces proliferation of Ba/F3 cells expressing human MPL (EC50 = 84 nM) but not of those expressing mouse Mpl; increases the number of circulating platelets in a transgenic mouse model expressing human MPL at 0.3-10 mg/kg per day and increases the number of megakaryocytes in the bone marrow at 10 mg/kg per day

Lusutrombopag – 10 mg

Brand:
Cayman
CAS:
1110766-97-6
Storage:
-20
UN-No:
Non-Hazardous - /

Lusutrombopag is an agonist of the thrombopoietin receptor.{45125} It induces proliferation of Ba/F3 cells expressing human MPL, the gene for the thrombopoietin receptor, with an EC50 value of 84 nM but not of those expressing mouse Mpl.{45126} Lusutrombopag (0.3-10 mg/kg per day) increases the number of circulating platelets in a transgenic mouse model expressing human MPL and increases the number of megakaryocytes in the bone marrow when administered at a dose of 10 mg/kg per day. Formulations containing lusutrombopag have been used in the treatment of thrombocytopenia in adult patients with chronic liver disease scheduled to undergo invasive procedures.  

 

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SKU: 26533 - 10 mg Category:

Description

A thrombopoietin receptor agonist; induces proliferation of Ba/F3 cells expressing human MPL (EC50 = 84 nM) but not of those expressing mouse Mpl; increases the number of circulating platelets in a transgenic mouse model expressing human MPL at 0.3-10 mg/kg per day and increases the number of megakaryocytes in the bone marrow at 10 mg/kg per day

Formal name: (2E)-3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-2-propenoic acid

Synonyms: 

Molecular weight: 591.5

CAS: 1110766-97-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Blood||Research Area|Immunology & Inflammation|Autoimmunity

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