An HIV-1 integrase inhibitor (IC50 = 7.5 nM for strand transfer activity); has antiviral activity against clinical isolates of HIV-1 in PBMCs (EC50s = 0.04-1.7 nM); inhibits HIV-1 viral infection in MT-2 and MT-4 cells

Bictegravir – 10 mg

Brand:
Cayman
CAS:
1611493-60-7
Storage:
-20
UN-No:
Non-Hazardous - /

Bictegravir is an inhibitor of HIV-1 integrase (IC50 = 7.5 nM for strand transfer activity).{47145} It has antiviral activity against clinical isolates of HIV-1 in human peripheral blood mononuclear cells (PBMCs; EC50s = 0.04-1.7 nM). Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively) without exhibiting cytotoxicity (CC50s = 10.3, 3.7, 13, and 29.8 μM, respectively).  

 

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SKU: 26532 - 10 mg Category:

Description

An HIV-1 integrase inhibitor (IC50 = 7.5 nM for strand transfer activity); has antiviral activity against clinical isolates of HIV-1 in PBMCs (EC50s = 0.04-1.7 nM); inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively)

Formal name: (2R,5S,13aR)-2,3,4,5,7,9,13,13a-octahydro-8-hydroxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Synonyms:  GS-9883

Molecular weight: 449.4

CAS: 1611493-60-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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