An internal standard for the quantification of tolvaptan by GC- or LC-MS

Tolvaptan-d7 – 5 mg

Brand:
Cayman
CAS:
1246818-18-7
Storage:
-20
UN-No:
Non-Hazardous - /

Tolvaptan-d7 is intended for use as an internal standard for the quantification of tolvaptan (Item No. 19691) by GC- or LC-MS. Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.{31703} It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.{43556} Formulations containing tolvaptan have been used to treat hyponatremia.  

 

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SKU: 26453 - 5 mg Category:

Description

An internal standard for the quantification of tolvaptan by GC- or LC-MS

Formal name: N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-6-(methyl-d3)-benzamide-2,3,4,5-d4

Synonyms: 

Molecular weight: 456

CAS: 1246818-18-7

Purity: ≥99% deuterated forms (d1-d7)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Kidney & Renal Disease

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