An internal standard for the quantification of dofetilide by GC- or LC-MS

Dofetilide-d4 – 1 mg

Brand:
Cayman
CAS:
1189700-56-8
Storage:
-20
UN-No:
Non-Hazardous - /

Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Item No. 15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}  

 

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SKU: 26451 - 1 mg Category:

Description

An internal standard for the quantification of dofetilide by GC- or LC-MS

Formal name: N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl-1,1,2,2-d4]amino]ethyl]phenyl]-methanesulfonamide

Synonyms: 

Molecular weight: 445.6

CAS: 1189700-56-8

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Research Area|Cardiovascular System|Heart|Arrhythmia

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