An internal standard for the quantification of topiramate by GC- or LC-MS

Topiramate-d12 – 1 mg

Brand:
Cayman
CAS:
1279037-95-4
Storage:
-20
UN-No:
Non-Hazardous - /

Topiramate-d12 is intended for use as an internal standard for the quantification of topiramate (Item No. 13623) by GC- or LC-MS. Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.  

 

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SKU: 26443 - 1 mg Category:

Description

An internal standard for the quantification of topiramate by GC- or LC-MS

Formal name: ((3aS,5aR,8aR,8bS)-2,2,7,7-tetrakis(methyl-d3)tetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methyl sulfamate

Synonyms:  TPM-d12

Molecular weight: 351.4

CAS: 1279037-95-4

Purity: ≥99% deuterated forms (d1-d12)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Carbonic Anhydrase||Research Area|Neuroscience|Pain Research||Research Area|Neuroscience|Seizure Disorders

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