A glycosylated hydroquinone with diverse biological activities; inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates

Arbutin – 5 g

Brand:
Cayman
CAS:
497-76-7
Storage:
-20
UN-No:
Non-Hazardous - /

Arbutin is a glycosylated hydroquinone that has been found in Arctostaphylos plants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, and anti-inflammatory properties.{42646,42647} It inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM).{42648} Arbutin (50 μM) inhibits hemolysis induced by the free radical generator AAPH (Item No. 82235) in sheep erythrocytes and inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts when used at concentrations greater than 125 μM.{42647} In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum.{42649} Formulations containing arbutin have been used in the treatment of hyperpigmentation disorders.{42646,42648}  

 

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SKU: 26407 - 5 g Category:

Description

A glycosylated hydroquinone with diverse biological activities; inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM); inhibits AAPH-induced hemolysis in sheep erythrocytes at 50 μM; inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts at >125 μM; prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum in an LPS-induced rat model of acute lung injury at 50 mg/kg

Formal name: 4-hydroxyphenyl β-D-glucopyranoside

Synonyms:  NSC 4036|β-Arbutin

Molecular weight: 272.3

CAS: 497-76-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Research Area|Immunology & Inflammation|Pulmonary Diseases||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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