A glycoside with diverse biological activities; scavenges DPPH and ABTS radicals and inhibits nitrite production in vitro from 0.1-3 mM; induces production of TNF-α

Bergenin – 1 g

Brand:
Cayman
CAS:
477-90-7
Storage:
-20
UN-No:
Non-Hazardous - /

Bergenin is a glycoside and a major constituent of Peltophorum plants and has diverse biological activities.{43645,43646,43647,43648} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS radicals and inhibits nitrite production in vitro when used at concentrations ranging from 0.1 to 3 mM.{43645} Bergenin induces production of TNF-α, nitric oxide (NO), and IL-12 in M. tuberculosis-infected macrophages.{43646} In vivo, bergenin reduces pulmonary lesion formation and bacterial load in mice infected with M. tuberculosis H37Rv. Bergenin (10 mg/kg, i.p) restores activity of mitochondrial complex I, II, and IV and reduces renal lipid peroxidation, IL-1β production, and shrinkage of glomeruli in a rat model of ethylene glycol-induced renal injury.{43647} It also prevents arrhythmias induced by coronary artery ligation and reperfusion and BaCl2 in mice.{43648}  

 

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SKU: 26406 - 1 g Category:

Description

A glycoside with diverse biological activities; scavenges DPPH and ABTS radicals and inhibits nitrite production in vitro from 0.1-3 mM; induces production of TNF-α, NO, and IL-12 in M. tuberculosis-infected macrophages; reduces pulmonary lesion formation and bacterial load in mice infected with M. tuberculosis H37Rv; restores activity of mitochondrial complex I, II, and IV and reduces renal lipid peroxidation, IL-1β production, and shrinkage of glomeruli in a rat model of ethylene glycol-induced renal injury at 10 mg/kg; prevents arrhythmias induced by coronary artery ligation and reperfusion and BaCl2 in mice

Formal name: (2R,3S,4S,4aR,10bS)-3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-pyrano[3,2-c][2]benzopyran-6(2H)-one

Synonyms:  (–)-Bergenin|Cuscutin|NSC 661749

Molecular weight: 328.3

CAS: 477-90-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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