An NNRTI; inhibits HIV reverse transcriptase (IC50 = 11 nM); inhibits the spread of wild-type HIV and K103N

Doravirine – 5 mg

Brand:
Cayman
CAS:
1338225-97-0
Storage:
-20
UN-No:
Non-Hazardous - /

Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits HIV reverse transcriptase (IC50 = 11 nM).{48085} It inhibits the spread of wild-type HIV and K103N, Y181C, and K103N/Y181C mutant HIV strains in cells cultured with 50% normal human serum (IC95s = 19, 42, 25, and 54 nM, respectively). Formulations containing doravirine have been used in the treatment of HIV-1 infection.  

 

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SKU: 26405 - 5 mg Category:

Description

An NNRTI; inhibits HIV reverse transcriptase (IC50 = 11 nM); inhibits the spread of wild-type HIV and K103N, Y181C, and K103N/Y181C mutant HIV strains in cells cultured with 50% normal human serum (IC95s = 19, 42, 25, and 54 nM, respectively)

Formal name: 3-chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]-benzonitrile

Synonyms:  MK-1439

Molecular weight: 425.8

CAS: 1338225-97-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals|Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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