An iridoid glycoside with diverse biological activities; reduces 6-OHDA-induced neurotoxicity in SH-SY5Y cells at 10 μM; reduces high glucose-induced levels of cleaved caspase-3 protein and apoptosis in mouse glomerular mesangial cells at 25

Specnuezhenide – 1 mg

Brand:
Cayman
CAS:
449733-84-0
Storage:
-20
UN-No:
Non-Hazardous - /

Specneuzhenide is an iridoid glycoside originally isolated from L. lucidum with diverse biological activities.{45121,45122,45123,45124} It reduces neurotoxicity induced by 6-OHDA (Item No. 25330) in SH-SY5Y cells by 49.2% when used at a concentration of 10 μM.{45121} Specneuzhenide (25, 50, and 100 μM) reduces high glucose-induced levels of cleaved caspase-3 protein and apoptosis in mouse glomerular mesangial cells.{45122} It increases cell viability and alkaline phosphatase activity in osteoblastic UMR-106 cells.{45123} Specneuzhenide inhibits hypoxia-induced VEGFA secretion, VEGFA and prolyl hydroxylase 2 (PHD-2) mRNA expression, and protein levels of VEGFA, HIF-1α, and PHD-2 in human acute retinal pigment epithelial-19 (ARPE-19) cells.{45124} In vivo, specneuzhenide (5 and 10 mg/kg) prevents retinal neovascularization in a rat model of oxygen-induced retinopathy.  

 

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SKU: 26385 - 1 mg Category:

Description

An iridoid glycoside with diverse biological activities; reduces 6-OHDA-induced neurotoxicity in SH-SY5Y cells at 10 μM; reduces high glucose-induced levels of cleaved caspase-3 protein and apoptosis in mouse glomerular mesangial cells at 25, 50, and 100 μM; increases cell viability and alkaline phosphatase activity in osteoblastic UMR-106 cells; inhibits hypoxia-induced VEGFA secretion, VEGFA and PHD-2 mRNA expression, and protein levels of VEGFA, HIF-1α, and PHD-2 in ARPE-19 cells; prevents retinal neovascularization in a rat model of oxygen-induced retinopathy at 5 and 10 mg/kg

Formal name: 2-(4-hydroxyphenyl)ethyl, 6-[(2S,3Z,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate], β-D-glucopyranoside

Synonyms:  8(Z)-Nuzhenide

Molecular weight: 686.7

CAS: 449733-84-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Neuroscience|Neuroprotection||Research Area|Neuroscience|Ophthalmology

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