A positive allosteric modulator of the M2 and M4 mAChRs; binds to allosteric sites on M2 and M4 receptors (KBs = 1.8-3.4 μM; potentiates the activity of ACh

LY2119620 – 1 mg

Brand:
Cayman
CAS:
886047-22-9
Storage:
-20
UN-No:
Non-Hazardous - /

LY2119620 is a positive allosteric modulator of the M2 and M4 muscarinic acetylcholine receptors (mAChRs).{48128} It binds to allosteric sites on M2 and M4 receptors with KB values ranging from 1.8 to 3.4 μM. LY2119620 potentiates the activity of the AChR agonist acetylcholine (ACh; Item No. 23829) and the mAChR agonists iperoxo and oxotremorine M (Item No. 20847) at human recombinant M2 and M4 receptors expressed in CHO cell membranes. LY2119620 also exhibits allosteric agonism at M2 and M4 receptors (23.2 and 16.8%, respectively, of the maximal ACh response).  

 

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SKU: 26373 - 1 mg Category:

Description

A positive allosteric modulator of the M2 and M4 mAChRs; binds to allosteric sites on M2 and M4 receptors (KBs = 1.8-3.4 μM; potentiates the activity of ACh, iperoxo, and oxotremorine M at human recombinant M2 and M4 receptors expressed in CHO cell membranes; exhibits allosteric agonism at M2 and M4 receptors (23.2 and 16.8%, respectively, of the maximal ACh response)

Formal name: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide

Synonyms: 

Molecular weight: 437.9

CAS: 886047-22-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area

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