An activator of Wnt/β-catenin signaling; increases β-catenin responsive transcription in a cell-based reporter assay in a concentration-dependent manner; increases β-catenin protein levels in HEK293 cells at 10 and 30 μM; disrupts the interaction between Axin and β-catenin; increases ALP activity and mineralization in multipotent mesenchymal ST2 cells

SKL2001 – 100 mg

Brand:
Cayman
CAS:
909089-13-0
Storage:
-20
UN-No:
Non-Hazardous - /

SKL2001 is an activator of Wnt/β-catenin signaling.{47093,47094} It increases β-catenin responsive transcription in a cell-based reporter assay in a concentration-dependent manner, increases β-catenin protein levels in HEK293 cells when used at concentrations of 10 and 30 μM, and disrupts the interaction between Axin and β-catenin.{47093} SKL2001 increases alkaline phosphatase (ALP) activity and mineralization in multipotent mesenchymal ST2 cells in a concentration-dependent manner, indicating increased osteoblastogenesis. SKL2001 (40 μM) reduces HCT116 and HT-29 spheroid growth and inhibits proliferation of HCT116 and HT-29 cells.{47094} It induces cell cycle arrest at the G0/G1 phase and increases E-cadherin and β-catenin protein levels in HCT116 cells when used at a concentration of 40 μM.  

 

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SKU: 26334 - 100 mg Category:

Description

An activator of Wnt/β-catenin signaling; increases β-catenin responsive transcription in a cell-based reporter assay in a concentration-dependent manner; increases β-catenin protein levels in HEK293 cells at 10 and 30 μM; disrupts the interaction between Axin and β-catenin; increases ALP activity and mineralization in multipotent mesenchymal ST2 cells, indicating increased osteoblastogenesis; reduces HCT116 and HT-29 spheroid growth and inhibits proliferation of HCT116 and HT-29 cells at 40 μM; induces cell cycle arrest at G0/G1 phase and increases E-cadherin and β-catenin protein levels in HCT116 cells at 40 μM

Formal name: 5-(2-furanyl)-N-[3-(1H-imidazol-1-yl)propyl]-3-isoxazolecarboxamide

Synonyms:  Wnt Agonist II

Molecular weight: 286.3

CAS: 909089-13-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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