A modulator of HBV capsid assembly; reduces viral DNA load in HBV-infected HepG2.2.15 cells (EC50 = 121 nM) without affecting cell growth; reduces viral DNA load in primary human hepatocytes infected with the HBV genotypes Ae

JNJ-632 – 1 mg

Brand:
Cayman
CAS:
1572510-42-9
Storage:
-20
UN-No:
Non-Hazardous - /

JNJ-632 is a modulator of hepatitis B virus (HBV) capsid assembly.{42633,42634} It reduces viral DNA load in HBV-infected HepG2.2.15 cells (EC50 = 121 nM) without affecting cell growth.{42634} It also reduces viral DNA load in primary human hepatocytes infected with the HBV genotypes Ae, Bj, C, and D (EC50s = 101, 240, 119, and 200 nM, respectively). JNJ-632 prevents formation of covalently closed circular DNA in HBV-infected primary human hepatocytes in a concentration-dependent manner when administered in combination with the HBV viral inoculum. In vivo, JNJ-632 (200 mg/kg per day) reduces plasma HBV DNA content in HBV-infected humanized mice.{42633}  

 

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SKU: 26325 - 1 mg Category:

Description

A modulator of HBV capsid assembly; reduces viral DNA load in HBV-infected HepG2.2.15 cells (EC50 = 121 nM) without affecting cell growth; reduces viral DNA load in primary human hepatocytes infected with the HBV genotypes Ae, Bj, C, and D (EC50s = 101, 240, 119, and 200 nM, respectively); prevents formation of covalently closed circular DNA in HBV-infected primary human hepatocytes in a concentration-dependent manner when administered in combination with the HBV viral inoculum; reduces plasma HBV DNA content in HBV-infected humanized mice at 200 mg/kg per day ,

Formal name: N-(4-fluoro-3-methylphenyl)-3-[[[(3S)-tetrahydro-3-furanyl]amino]sulfonyl]-benzamide

Synonyms: 

Molecular weight: 378.4

CAS: 1572510-42-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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