A 5-LO inhibitor (IC50 = 5 µM for A23187-stimulated 5-LO product synthesis in isolated human granulocytes); inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-

Lipoxygenin – 10 mg

Brand:
Cayman
CAS:
2247911-68-6
Storage:
-20
UN-No:
Non-Hazardous - /

Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 5 µM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 (Item No. 22030).{48965} It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 µM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 µM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 (Item No. 13122).  

 

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SKU: 26310 - 10 mg Category:

Description

A 5-LO inhibitor (IC50 = 5 µM for A23187-stimulated 5-LO product synthesis in isolated human granulocytes); inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, BMP-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 µM, respectively, in luciferase reporter assays); increases TnnT levels in BMP4- and CHIR99021-stimulated human iPSCs

Formal name: 2′,4,6-trimethoxy-α-2-naphthalenyl-[3,3′-bipyridine]-5-methanol

Synonyms: 

Molecular weight: 402.4

CAS: 2247911-68-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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