A fungal metabolite; inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 µM

Bis(methylthio)gliotoxin – 500 µg

Brand:
Cayman
CAS:
74149-38-5
Storage:
-20
UN-No:
Non-Hazardous - /

Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities.{36971} It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 µM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 µM).{36972} Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 µM).{36973} It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin (Item No. 11433).{36972,36974} Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.{36975}  

 

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Description

A fungal metabolite; inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 µM, respectively); inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 µM); inhibits PAF-induced bronchoconstriction in guinea pigs at 0.1 mg/kg; less toxic to mice (LD50 = >500 mg/kg) than gliotoxin; has been used as a serum biomarker in patients infected with invasive aspergillosis

Formal name: (3R,5aS,6S,10aR)-2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-pyrazino[1,2-a]indole-1,4-dione

Synonyms:  Bisdethiobis(methylthio)gliotoxin|FR 49175

Molecular weight: 356.5

CAS: 74149-38-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Immunology & Inflammation|Pulmonary Diseases

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