A pleiotropic pathway modifier with anticancer activity; binds to cereblon in U266 multiple myeloma cell extracts; induces recruitment and degradation of Aiolos and Ikaros in TMD8

CC-122 – 5 mg

Brand:
Cayman
CAS:
1015474-32-4
Storage:
-20
UN-No:
Non-Hazardous - /

CC-122 is a pleiotropic pathway modifier with anticancer activity.{50163} It binds to cereblon, a substrate receptor protein of the Cullin 4 RING E3 ubiquitin ligase complex, in U266 multiple myeloma cell extracts and induces recruitment and degradation of the cereblon substrates Aiolos and Ikaros in TMD8, OCI-LY10, and Karpas 422 diffuse large B cell lymphoma (DLBCL) cells when used at concentrations of 0.1, 1, and 10 μM. CC-122 (0.1-10,000 nM) decreases proliferation and induces apoptosis in activated B cell (ABC) and germinal center B cell (GCB) DLBCL cell lines. It also stimulates IL-2 production in mouse primary T cells. CC-122 (30 mg/kg) decreases tumor levels of Aiolos and Ikaros and reduces tumor growth in OCI-LY10 ABC DLBCL and WSU-DLCL2 GCB DLBCL mouse xenograft models.  

 

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Description

A pleiotropic pathway modifier with anticancer activity; binds to cereblon in U266 multiple myeloma cell extracts; induces recruitment and degradation of Aiolos and Ikaros in TMD8, OCI-LY10, and Karpas 422 DLBCL cells at 0.1, 1, and 10 μM; decreases proliferation and induces apoptosis ABC and GCB DLBCL cell lines from 0.1-10,000 nM; stimulates IL-2 production in mouse primary T cells; decreases tumor levels of Aiolos and Ikaros and reduces tumor growth in OCI-LY10 ABC DLBCL and WSU-DLCL2 GCB DLBCL mouse xenograft models

Formal name: 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-2,6-piperidinedione

Synonyms:  Avadomide

Molecular weight: 286.3

CAS: 1015474-32-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Adaptive Immunity

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