A furanocoumarin derivative with diverse biological activities; decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner

Bergapten – 10 g

Brand:
Cayman
CAS:
484-20-8
Storage:
-20
UN-No:
Non-Hazardous - /

Bergapten is a furanocoumarin derivative that has been found in grapefruit peel oil and has diverse biological activities.{22311,47434,47435,47436} It decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner, halts the cell cycle at the G0/G1 and sub-G1 phases, and induces apoptosis when used at a concentration of 50 μM.{47434} Bergapten has photosensitizing activity and increases the number of sunburn cells in guinea pig skin in response to UVA radiation.{47435} It increases the pain threshold in assays for mechanical, cold, and hot allodynia, as well as mechanical hyperalgesia, in a rat model of vincristine-induced neuropathic pain when administered at a dose of 10 mg/kg. {47436} Bergapten inhibits vincristine-induced increases in plasma TNF-α and IL-1β levels and decreases in glutathione (GSH) levels in the spinal cord and sciatic nerve in rats. It also inhibits the cytochrome P450 (CYP) isoform CYP3A4 with IC50 value of approximately 25 μM in human liver microsomes.{22311}  

 

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SKU: 26254 - 10 g Category:

Description

A furanocoumarin derivative with diverse biological activities; decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner, halts the cell cycle at the G0/G1 and sub-G1 phases, and induces apoptosis at 50 μM; has photosensitizing activity; increases the number of sunburn cells in guinea pig skin in response to UVA radiation; increases the pain threshold in assays for mechanical, cold, and hot allodynia, as well as mechanical hyperalgesia, in a rat model of vincristine-induced neuropathic pain at 10 mg/kg; inhibits vincristine-induced increases in plasma TNF-α and IL-1β levels and decreases in GSH levels in the spinal cord and sciatic nerve in rats; inhibits CYP3A4 (IC50 = ~25 μM) in human liver microsomes

Formal name: 4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one

Synonyms:  5-Methoxypsoralen|5-MOP|Heraclin|NSC 95437

Molecular weight: 216.2

CAS: 484-20-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Pain Research||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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