Description
A disulfide with diverse biological activities; active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml); cytotoxic to mouse melanoma cells (IC50 = 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM); reduces tumor growth in a B16/BL6 mouse model of melanoma at 25 µg/kg every other day and decreases the number of lung metastases when administered prior to tumor cell inoculation at 1-25 µg/g; inhibits ADP- or collagen-induced platelet aggregation in isolated baboon platelets at 75-100 µg/ml and in platelet-rich plasma isolated from baboons at 25 mg/kg; prevents thrombus formation on damaged arterial walls in heparinized pigs in an in situ model of thrombogenesis at 25 mg/kg; reduces high-fat diet-induced hepatic steatosis, histopathological markers of liver damage, TBARS formation, and protein oxidation in a mouse model of NAFLD
Formal name: 2-propen-1-yl[3-(2-propen-1-ylsulfinyl)-1-propen-1-yl] disulfide
Synonyms:
Molecular weight: 234.4
CAS: 92285-01-3
Purity: ≥95%
Formulation: A solution in ethyl acetate
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Protein Oxidation
