An inhibitor of p75NTR- and NRAGE-induced apoptosis; inhibits JNK signaling

AEG 3482 – 25 mg

Brand:
Cayman
CAS:
63735-71-7
Storage:
-20
UN-No:
Non-Hazardous - /

AEG 3482 is an inhibitor of p75NTR- and NRAGE-induced apoptosis.{49017} It inhibits JNK signaling, caspase-3 cleavage, and cell death induced by the p75 neurotrophin receptor (p75NTR) or the p75NTR-interacting protein NRAGE in PC12rtTA cells in a concentration-dependent manner. AEG 3482 inhibits cell death induced by withdrawal of nerve growth factor (NGF) in rat SCG neurons (EC50 = ~20 μM). It also increases Hsp70 and Hsp25 levels in mouse embryonic fibroblasts (MEFs) in an HSF1-dependent manner and binds to recombinant Hsp90.  

 

Available on backorder

Add to quotes
SKU: 26213 - 25 mg Category:

Description

An inhibitor of p75NTR- and NRAGE-induced apoptosis; inhibits JNK signaling, caspase-3 cleavage, and cell death induced by p75NTR or NRAGE in PC12rtTA cells in a concentration-dependent manner; inhibits cell death induced by withdrawal of NGF in rat SCG neurons (EC50 = ~20 μM); increases Hsp70 and Hsp25 levels in MEFs in an HSF1-dependent manner; binds recombinant Hsp90

Formal name: 6-phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

Synonyms: 

Molecular weight: 280.3

CAS: 63735-71-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

Related products

  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 50 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 1 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 1 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 25 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 25 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 50 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 50 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page