An inhibitor of fatty acid transport; inhibits C1-BODIPY-C12 uptake in HepG2

Grassofermata – 5 mg

Brand:
Cayman
CAS:
419547-11-8
Storage:
-20
UN-No:
Non-Hazardous - /

Grassofermata is an inhibitor of fatty acid transport.{43557} It inhibits C1-BODIPY-C12 uptake in HepG2, Caco-2, C2C12, and INS-1E cells (IC50s = 8.1-10.6 μM).{43557} Grassofermata prevents palmitate-mediated lipid accumulation and cell death in HepG2 cells and primary hepatocytes. In vivo, grassofermata (300 mg/kg) decreases absorption of 13C-oleate in mice.  

 

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Description

An inhibitor of fatty acid transport; inhibits C1-BODIPY-C12 uptake in HepG2, Caco-2, C2C12, and INS-1E cells (IC50s = 8.1-10.6 μM); prevents palmitate-mediated lipid accumulation and cell death in HepG2 cells and primary hepatocytes; decreases absorption of 13C-oleate in mice at 300 mg/kg

Formal name: 3-(4-chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one

Synonyms:  NAV2729

Molecular weight: 456.9

CAS: 419547-11-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area

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