A ROCK-I and GRK2 inhibitor (IC50s = 14 and 0.77 µM

GSK180736A – 5 mg

Brand:
Cayman
CAS:
817194-38-0
Storage:
-20
UN-No:
De Minimis - 3077 / 9

GSK180736A is an inhibitor of Rho-associated kinase 1 (ROCK-I; IC50 = 14 nM) and G protein-coupled receptor kinase 2 (GRK2; IC50 = 0.77 µM).{26327,42595} It is selective for GRK2 over GRK1, GRK5, and PKA (IC50 = >100 µM for all) and selective for ROCK-I over RSK1 and p20S6K (IC50s = 3,100 and 2,850 nM, respectively).{26327,42595} GSK180736A increases maximum contractility in isolated mouse cardiomyocytes when used at a concentration of 1 µM.{42595}  

 

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SKU: 26182 - 5 mg Category:

Description

A ROCK-I and GRK2 inhibitor (IC50s = 14 and 0.77 µM, respectively); selective for GRK2 over GRK1, GRK5, and PKA (IC50 = >100 µM for all); selective for ROCK-I over RSK1 and p20S6K (IC50s = 3,100 and 2,850 nM, respectively); increases maximum contractility in isolated mouse cardiomyocytes at 1 µM

Formal name: 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-5-pyrimidinecarboxamide

Synonyms: 

Molecular weight: 365.4

CAS: 817194-38-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Kinase Inhibitors|ROCK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Heart|Myocardial Contractility

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