A GPR119 agonist (EC50 = 43.9 nM in CHO-K1 cells expressing human GPR119); inhibits T0901317-induced increases in SREBP-1 levels and increases activation of AMPK in HepG2 cells in a concentration-dependent manner; inhibits BCRP and OATP1B1 by 52 and 40%

GSK1292263 – 50 mg

Brand:
Cayman
CAS:
1032823-75-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

GSK1292263 is an agonist of G protein-coupled receptor 119 (GPR119; EC50 = 43.9 nM in CHO-K1 cells expressing human receptors).{47194} It inhibits increases in sterol regulatory element binding protein-1 (SREBP-1) levels induced by the LXR agonist T0901317 and increases activation of AMPK in HepG2 cells in a concentration-dependent manner.{36741} GSK1292263 also inhibits breast cancer resistant protein (BCRP) and organic anion transporting polypeptide 1B1 (OATP1B1) by 52 and 40%, respectively, when used at a concentration of 3 μM.{47195}  

 

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SKU: 26181 - 50 mg Category:

Description

A GPR119 agonist (EC50 = 43.9 nM in CHO-K1 cells expressing human GPR119); inhibits T0901317-induced increases in SREBP-1 levels and increases activation of AMPK in HepG2 cells in a concentration-dependent manner; inhibits BCRP and OATP1B1 by 52 and 40%, respectively, at 3 μM

Formal name: 5-[[1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl]methoxy]-2-[4-(methylsulfonyl)phenyl]-pyridine

Synonyms: 

Molecular weight: 456.6

CAS: 1032823-75-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology||Research Area|Endocrinology & Metabolism|Nutrient Sensing||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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