An ALK and IGF-1R inhibitor; inhibits ALK (IC50 = 15 nM); inhibits the proliferation of neuroblastoma cells with WT ALK (IC50s = 2.8-21.3 µM) or ALK containing activating mutations (IC50s = 1.7 and 16.49 µM for ALKF1174L and ALKD1091N

AZD 3463 – 5 mg

Brand:
Cayman
CAS:
1356962-20-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

AZD 3463 is an inhibitor of anaplastic lymphoma kinase (ALK) and the insulin growth factor-1 receptor (IGF-1R).{43620} It inhibits ALK with an IC50 value of 15 nM.{38680} It inhibits the proliferation of neuroblastoma cells with wild-type (WT) ALK (IC50s = 2.8-21.3 µM) and ALK with the activating mutations ALKF1174L and ALKD1091N (IC50s = 1.7 and 16.49 µM, respectively) and induces apoptosis and autophagy.{43620} It reduces tumor growth in neuroblastoma mouse xenograft models expressing WT ALK or the ALKF1174L mutation when administered at a dose of 15 mg/kg per day for 21 days.  

 

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Description

An ALK and IGF-1R inhibitor; inhibits ALK (IC50 = 15 nM); inhibits the proliferation of neuroblastoma cells with WT ALK (IC50s = 2.8-21.3 µM) or ALK containing activating mutations (IC50s = 1.7 and 16.49 µM for ALKF1174L and ALKD1091N, respectively); reduces tumor growth in neuroblastoma mouse xenograft models expressing WT ALK or the ALKF1174L mutation at 15 mg/kg per day for 21 days

Formal name: N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine

Synonyms: 

Molecular weight: 449

CAS: 1356962-20-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IGF-1R/InsR Family||Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling

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