An active metabolite of clozapine; originally described as an antagonist of 5-HT2C receptors (IC50 = 7.1 nM in rat choroid plexus); and later as an inverse agonist using human recombinant receptors; an antagonist at dopamine D4 receptors

N-Desmethylclozapine – 5 mg

Brand:
Cayman
CAS:
6104-71-8
Storage:
-20
UN-No:
Non-Hazardous - /

N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine (Item Nos. 12059 | 25779).{25512} It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50 = 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.{47099,47100} N-Desmethylclozapine is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors.{47100,25512,47101} N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibition of the acoustic startle response in mice.{47102}  

 

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SKU: 26153 - 5 mg Category:

Description

An active metabolite of clozapine; originally described as an antagonist of 5-HT2C receptors (IC50 = 7.1 nM in rat choroid plexus); and later as an inverse agonist using human recombinant receptors; an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors; decreases exploratory locomotor activity and increases prepulse inhibition of the acoustic startle response in mice at 30 mg/kg,

Formal name: 8-chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Synonyms:  Norclozapine

Molecular weight: 312.8

CAS: 6104-71-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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