Description
An active metabolite of clozapine; originally described as an antagonist of 5-HT2C receptors (IC50 = 7.1 nM in rat choroid plexus); and later as an inverse agonist using human recombinant receptors; an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors; decreases exploratory locomotor activity and increases prepulse inhibition of the acoustic startle response in mice at 30 mg/kg,
Formal name: 8-chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Synonyms: Norclozapine
Molecular weight: 312.8
CAS: 6104-71-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis
