Description
A dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively); stimulates [35S]GTPγS binding to cell membranes expressing μ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively); decreases capsaicin-induced thermal allodynia without increasing scratching activity in rhesus monkeys from 0.003-0.03 mg/kg; lacks reinforcing effects and reduces oxycodone reinforcement in a drug self-administration assay in rhesus monkeys from 0.3-10 μg/kg per injection; does not induce hyperalgesia in rhesus monkeys at 0.01 or 0.03 mg/kg
Formal name: N-[2-[1,2-dihydro-1′-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4′-piperidin]-2-yl]ethyl]-sulfamide
Synonyms:
Molecular weight: 462.6
CAS: 2099681-31-7
Purity: ≥95%
Formulation: A solution in chloroform
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Pain Research
