A PROTAC building block; contains thalidomide

Azido-Thalidomide – 25 mg

Brand:
Cayman
CAS:
2098488-36-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Azido-thalidomide is a building block in the synthesis of proteolysis-targeting chimera (PROTAC) technologies.{46112} It contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry. Azido-thalidomide has been used in the synthesis of a SirReal-based PROTAC for the degradation of sirtuin 2 (Sirt2) in cells.  

 

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SKU: 26146 - 25 mg Category:

Description

A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells

Formal name: N-(4-azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-acetamide

Synonyms: 

Molecular weight: 428.4

CAS: 2098488-36-7

Purity: ≥95%

Formulation: A crystalline solid

Application|Click Chemistry||Product Type|Biochemicals|PROTACs||Product Type|Biochemicals|Synthetic Intermediates & Building Blocks||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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