An inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8

Heclin – 1 mg

Brand:
Cayman
CAS:
890605-54-6
Storage:
-20
UN-No:
Non-Hazardous - /

Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively).{43931} It inhibits autoubiquitination of Smurf2 in HEK293 cells expressing the human enzyme (IC50 = 9 μM) and reduces ubiquitination of Dishevelled 2 in HEK293 cells expressing Smurf2, Nedd4, or WWP2. Heclin is cytotoxic to HEK293 cells (IC50 = 45 μM).  

 

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SKU: 26139 - 1 mg Category:

Description

An inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively); inhibits autoubiquitination of Smurf2 in HEK293 cells expressing the human enzyme (IC50 = 9 μM); reduces ubiquitination of Dishevelled 2 in HEK293 cells expressing Smurf2, Nedd4, or WWP2; cytotoxic to HEK293 cells (IC50 = 45 μM)

Formal name: N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

Synonyms: 

Molecular weight: 283.3

CAS: 890605-54-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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