A Smurf1 inhibitor (Kd = 3.67 nM); inhibits Smurf1-mediated ubiquitination of Smad1/5 and increases Smad1/5 protein levels in C2C12 cells stimulated with BMP2; increases BMP2-induced mRNA expression of ALP

A01 – 50 mg

Brand:
Cayman
CAS:
1007647-73-5
Storage:
-20
UN-No:
Non-Hazardous - /

A01 is an inhibitor of Smad ubiquitination regulatory factor 1 (Smurf1) ubiquitin ligase (Kd = 3.67 nM).{47561} It inhibits Smurf1-mediated ubiquitination of Smad1/5 and increases Smad1/5 protein levels in C2C12 cells stimulated with bone morphogenic protein 2 (BMP2) in a concentration-dependent manner. A01 (2 μM) increases BMP2-induced mRNA expression of alkaline phosphatase (ALP), osteocalcin, and type-1 collagen in MC3T3-E1 mouse pre-osteoblasts.  

 

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SKU: 26137 - 50 mg Category:

Description

A Smurf1 inhibitor (Kd = 3.67 nM); inhibits Smurf1-mediated ubiquitination of Smad1/5 and increases Smad1/5 protein levels in C2C12 cells stimulated with BMP2; increases BMP2-induced mRNA expression of ALP, osteocalcin, and type-1 collagen in MC3T3-E1 mouse pre-osteoblasts at 2 μM

Formal name: [4-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]-methanone

Synonyms: 

Molecular weight: 512.9

CAS: 1007647-73-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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