An allosteric modulator of muscarinic acetylcholine receptors; slows the dissociation of the muscarinic antagonist [3H]NMS from M1-M5 muscarinic receptors

Gallamine (iodide) – 1 g

Brand:
Cayman
CAS:
65-29-2
Storage:
-20
UN-No:
Non-Hazardous - /

Gallamine is an allosteric modulator of muscarinic acetylcholine receptors.{45058} It slows the dissociation of the muscarinic antagonist [3H]NMS from M1-M5 muscarinic receptors, with the highest potency for M2 receptors. Gallamine is cardioselective, inhibiting [3H]NMS binding in rat heart tissue homogenates more potently than in other tissues (IC50s = 0.8 and 3-30 µM, respectively).{45059} Formulations containing gallamine have previously been used as neuromuscular blockers during surgery.  

 

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SKU: 26086 - 1 g Category:

Description

An allosteric modulator of muscarinic acetylcholine receptors; slows the dissociation of the muscarinic antagonist [3H]NMS from M1-M5 muscarinic receptors, with the highest potency for M2 receptors; inhibits [3H]NMS binding in rat heart tissue homogenates more potently than in other tissues (IC50s = 0.8 and 3-30 µM, respectively), indicating cardioselectivity

Formal name: 2,2′,2”-[1,2,3-benzenetriyltris(oxy)]tris[N,N,N-triethyl]-ethanaminium, triiodide

Synonyms: 

Molecular weight: 891.5

CAS: 65-29-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Cardiovascular System|Heart||Research Area|Neuroscience

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