An inhibitor of voltage-gated sodium channels (IC50 = 198 µM for inhibition of peak sodium currents evoked by step depolarizations in DRG neurons in vitro); acts as an antispastic agent that attenuates monosynaptic

Tolperisone (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
3644-61-9
Storage:
4
UN-No:
Non-Hazardous - /

Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro.{34788} Tolperisone acts as an antispastic agent that attenuates monosynaptic, disynaptic, and polysynaptic reflux response to dorsal root stimulation in vivo. Formulations containing tolperisone are used as analgesics and muscle relaxants.  

 

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Description

An inhibitor of voltage-gated sodium channels (IC50 = 198 µM for inhibition of peak sodium currents evoked by step depolarizations in DRG neurons in vitro); acts as an antispastic agent that attenuates monosynaptic, disynaptic, and polysynaptic reflux response to dorsal root stimulation in vivo

Formal name: 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone, monohydrochloride

Synonyms:  N-553

Molecular weight: 281.8

CAS: 3644-61-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Pain Research

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