Description
A furanocoumarin with diverse biological activities; decreases MCL-1 protein levels and increases mitochondrial membrane depolarization and apoptosis in R-HepG2 cells, an effect that can be reversed by overexpression of MCL-1; inhibits the growth of doxorubicin-resistant and -sensitive HepG2 cells (IC50s = 28.1 and 43.3 μM, respectively); reduces tumor growth in an R-HepG2 mouse xenograft model at 50 mg/kg; inhibits LPS-induced increases in p38 MAPK, JNK, and IκBα phosphorylation, TNF-α, IL-6, and IL-1β protein levels, and nuclear localization of NF-κB p65 in RAW 264.7 macrophages; scavenges DPPH and ABTS radicals (EC50s = 19.48 and 10.93 μM, respectively); has antibacterial, antiviral, and anticonvulsant activities
Formal name: 9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one
Synonyms: Marmelosin|NSC 402949
Molecular weight: 270.3
CAS: 482-44-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Multidrug Resistance||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Neuroscience|Seizure Disorders||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic
