A benzimidazole carbamate anthelmintic; completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model at 5 and 50 mg/kg per day

Flubendazole – 25 g

Brand:
Cayman
CAS:
31430-15-6
Storage:
4
UN-No:
Non-Hazardous - /

Flubendazole is a benzimidazole carbamate anthelmintic.{42565} It completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively.{42566} Flubendazole inhibits mammalian tubulin polymerization (IC50 = 2.5 µM) and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50 = 0.17 µM).{41688} Flubendazole also inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC50s = 0.72, 1.51, 1.75, and 5.51 µM, respectively) and reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg.{42568}  

 

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SKU: 26064 - 25 g Category:

Description

A benzimidazole carbamate anthelmintic; completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model at 5 and 50 mg/kg per day, respectively; inhibits mammalian tubulin polymerization (IC50 = 2.5 µM); inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50 = 0.17 µM); inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC50s = 0.72, 1.51, 1.75, and 5.51 µM, respectively); reduces tumor growth in an MDA-MB-231 mouse xenograft model at 25 mg/kg

Formal name: N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester

Synonyms:  NSC 313680|R-17889|R-17899

Molecular weight: 313.3

CAS: 31430-15-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases

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