An inhibitor of Cdc7 kinase (IC50 = 3.3 nM); inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 µM); LY3177833 reduces tumor growth in an SW620 mouse xenograft model at 10

LY3177833 – 5 mg

Brand:
Cayman
CAS:
1627696-51-8
Storage:
-20
UN-No:
Non-Hazardous - /

LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC50 = 3.3 nM for ADP production in an enzyme assay).{48053} It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 µM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day.  

 

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SKU: 25988 - 5 mg Category:

Description

An inhibitor of Cdc7 kinase (IC50 = 3.3 nM); inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 µM); LY3177833 reduces tumor growth in an SW620 mouse xenograft model at 10, 20, and 30 mg/kg twice per day

Formal name: (3R)-3-(5-fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-1H-isoindol-1-one

Synonyms: 

Molecular weight: 309.3

CAS: 1627696-51-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling

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