An atypical antipsychotic; binds to dopamine D2 and D3 receptors (Kis = 4.2 and 15 nM

(±)-Sulpiride – 50 mg

Brand:
Cayman
CAS:
15676-16-1
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-Sulpiride is an atypical antipsychotic that binds to dopamine D2 and D3 receptors (Kis = 4.2 and 15 nM, respectively).{41323} It is selective for dopamine D2 and D3 over D1 receptors and the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT3 (Kis = >10,000 nM). (±)-Sulpiride (0.5 or 1 ng per animal) increases attentional accuracy and decreases latency to respond correctly, the number of omissions, and impulsivity in the 5-choice serial reaction time task (5CSRTT) when infused directly into the nucleus accumbens in a rat model of prefrontal cortex lesion-induced attentional dysfunction.{46039} It increases cortical and striatal demethylation of hypermethylated reelin and GAD67 promoters in mice when administered at doses ranging from 12.5 to 50 μmol/kg twice per day for three days.{46040} Formulations containing (±)-sulpiride have been used in the treatment of schizophrenia.  

 

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Description

An atypical antipsychotic; binds to dopamine D2 and D3 receptors (Kis = 4.2 and 15 nM, respectively); selective for dopamine D2 and D3 over D1 receptors and 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT3 receptors (Kis = >10,000 nM); increases attentional accuracy and decreases latency to respond correctly, the number of omissions, and impulsivity in the 5CSRTT in rats at 0.5 or 1 ng per animal; increases cortical and striatal demethylation of hypermethylated reelin and GAD67 promoters in mice from 12.5 to 50 μmol/kg twice per day for 3 days

Formal name: 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide

Synonyms:  (RS)-(±)-Sulpiride|(S)-Sulpiride|rac-Sulpiride|RD 1403

Molecular weight: 341.4

CAS: 15676-16-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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