A steroid sapogenin; reduces the percentage of mobile larvae in goat fecal cultures containing Haemonchus

Hecogenin Acetate – 5 g

Brand:
Cayman
CAS:
915-35-5
Storage:
-20
UN-No:
Non-Hazardous - /

Hecogenin acetate is a steroid sapogenin and an acetylated form of hecogenin (Item No. 21372) that has anthelmintic and antinociceptive properties.{42489,42490,42491} It reduces the percentage of mobile larvae in goat fecal cultures containing Haemonchus, Oesophagostomum, and Trichostrongylus nematodes (EC50 = 0.49 mg/ml).{42489} Hecogenin acetate (5, 10, or 20 mg/kg, i.p.) inhibits development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine (Item No. 21992), and prostaglandin E2 (PGE2; Item No. 14010) in mice.{42490} It also increases latency to tail withdrawal in the tail flick test and has no effect on motor performance in the rotarod test in mice when administered at a dose of 40 mg/kg.{42491}  

 

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Description

A steroid sapogenin; reduces the percentage of mobile larvae in goat fecal cultures containing Haemonchus, Oesophagostomum, and Trichostrongylus nematodes (EC50 = 0.49 mg/ml); inhibits development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine, and PGE2 at 5, 10, or 20 mg/kg; increases latency to tail withdrawal in the tail flick test in mice at 40 mg/kg ,

Formal name: (3β,5α,25R)-3-(acetyloxy)-spirostan-12-one

Synonyms:  NSC 15489

Molecular weight: 472.7

CAS: 915-35-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Natural Products|Saponins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Neuroscience|Pain Research

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