An inhibitor of SMYD3; 100-fold selective for SMYD3 over other histone methyltransferases; inhibits methylation of MEKK2 peptide in a cell-free assay and in cells (IC50s = 88 and 70 nM

BAY-6035 – 10 mg

Brand:
Cayman
CAS:
2247890-13-5
Storage:
-20
UN-No:
Non-Hazardous - /

BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). It is 100-fold selective for SMYD3 over other histone methyltransferases. BAY-6035 inhibits methylation of MEKK2 peptide in a cell-free assay and in cells (IC50s = 88 and 70 nM, respectively). See the Structural Genomic Consortium (SGC) website for more information.  

 

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SKU: 25925 - 10 mg Category:

Description

An inhibitor of SMYD3; 100-fold selective for SMYD3 over other histone methyltransferases; inhibits methylation of MEKK2 peptide in a cell-free assay and in cells (IC50s = 88 and 70 nM, respectively)

Formal name: (2S)-1-(3-azabicyclo[3.1.0]hex-3-ylcarbonyl)-N-(2-cyclopropylethyl)-2,3,4,5-tetrahydro-2-methyl-4-oxo-1H-1,5-benzodiazepine-7-carboxamide

Synonyms: 

Molecular weight: 396.5

CAS: 2247890-13-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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