The (R) enantiomer of mephenytoin; can be demethylated by CYP2C9 to form the active metabolite 5-ethyl-5-phenylhydantoin (nirvanol); the ratio of (S)- to (R)-mephenytoin in urine following administration of the racemic mixture has been used to detect polymorphisms in drug metabolism by CYP2C19

(R)-Mephenytoin – 100 mg

Brand:
Cayman
CAS:
71140-51-7
Storage:
-20
UN-No:
Non-Hazardous - /

(R)-Mephenytoin is the (R) enantiomer of the anticonvulsant mephenytoin.{47078} (R)-Mephenytoin can be demethylated by the cytochrome P450 (CYP) isoform CYP2C9 to form the active metabolite 5-ethyl-5-phenylhydantoin (nirvanol).{47079,23860} The ratio of (S)-mephenytoin (Item No. 11913) to (R)-mephenytoin in urine following administration of the racemic mixture has been used to detect polymorphisms in drug metabolism by CYP2C19, as only (S)-mephenytoin is a substrate of CYP2C19.{23861,23857,47079}  

 

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SKU: 25891 - 100 mg Category:

Description

The (R) enantiomer of mephenytoin; can be demethylated by CYP2C9 to form the active metabolite 5-ethyl-5-phenylhydantoin (nirvanol); the ratio of (S)- to (R)-mephenytoin in urine following administration of the racemic mixture has been used to detect polymorphisms in drug metabolism by CYP2C19, as only (S)-mephenytoin is a substrate of CYP2C19

Formal name: (5R)-5-ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione

Synonyms:  ,(–)-Mephenytoin|(R)-5-ethyl-3-methyl-5-Phenylhydantoin

Molecular weight: 218.3

CAS: 71140-51-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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