A STING inhibitor; binds to Cys91 on STING to block its and prevents recruitment and phosphorylation of TBK1 in HEK293T cells; selectively reduces STING-

C-178 – 25 mg

Brand:
Cayman
CAS:
329198-87-0
Storage:
-20
UN-No:
Non-Hazardous - /

C-178 is a covalent inhibitor of stimulator of interferon genes (STING).{35390} It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 (0.01-1.25 µM) selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells. It also prevents increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs) induced by cyclic di-GMP (Item No. 17144), double-stranded DNA, and LPS when used at a concentration of 0.5 µM.  

 

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Description

A STING inhibitor; binds to Cys91 on STING to block its and prevents recruitment and phosphorylation of TBK1 in HEK293T cells; selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells from 0.01-1.25 µM; prevents increases in Ifnb1 expression induced by cyclic di-GMP, double-stranded DNA, and LPS in BMDMs at 0.5 µM

Formal name: N-3-dibenzofuranyl-5-nitro-2-furancarboxamide

Synonyms: 

Molecular weight: 322.3

CAS: 329198-87-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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