A STING inhibitor; reduces STING-

C-176 – 10 mg

Brand:
Cayman
CAS:
314054-00-7
Storage:
-20
UN-No:
Non-Hazardous - /

C-176 is a covalent inhibitor of stimulator of interferon genes (STING).{35390} It selectively reduces STING-, but not RIG-I or TBK1-, mediated IFN-β reporter activity in HEK293 cells when used at concentrations ranging from 0.01 to 5 μM. C-176 reduces serum levels of type-I interferons (IFNs) and cardiac inflammation in the Trex-/- mouse model of multi-organ inflammation.  

 

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SKU: 25859 - 10 mg Category:

Description

A STING inhibitor; reduces STING-, but not RIG-I or TBK1-, mediated IFN-β reporter activity in HEK293 cells from 0.01-5 μM; reduces serum levels of type-I IFNs and cardiac inflammation the in Trex-/- mouse model of multi-organ inflammation,

Formal name: N-(4-iodophenyl)-5-nitro-2-furancarboxamide

Synonyms: 

Molecular weight: 358.1

CAS: 314054-00-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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