A phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position; is produced via oxidation of SAPE by 15-LO; increases ferroptotic cell death in RSL3-treated wild-type and Acls4 knockout Pfa1 MEFs at 0.6 and 0.9 μM

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE – 1 mg

Brand:
Cayman
CAS:
154436-49-4
Storage:
-80
UN-No:
Excepted Quantity - 1170 / 3

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid (Item No. 10011298) at the sn-1 position and 15(S)-HpETE (Item No. 44720) at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE; Item No. 25871) by 15-lipoxygenase (15-LO).{43514} 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.{33037}  

 

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SKU: 25856 - 1 mg Category:

Description

A phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position; is produced via oxidation of SAPE by 15-LO; increases ferroptotic cell death in RSL3-treated wild-type and Acls4 knockout Pfa1 MEFs at 0.6 and 0.9 μM

Formal name: [S-[R*,S*-(E,Z,Z,Z)]]-15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, 2-[[(2-aminoethoxy)hydroxyphosphinyl]oxy]-1-[[(1-oxooctadecyl)oxy]methyl]ethyl ester

Synonyms:  ​15(S)-HpETE-SAPE|15(S)-hydroperoxyeicostetraenoic acid-SAPE|1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine

Molecular weight: 800.1

CAS: 154436-49-4

Purity: ≥90%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Glycerophospholipids||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Lipid Biochemistry|Glycerophospholipids||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways

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