A DGAT-1 inhibitor (IC50 = 15 nM); selective for DGAT-1 over DGAT-2 and ACAT-1 (IC50s = >10 and 12 μM

T-863 – 25 mg

Brand:
Cayman
CAS:
701232-20-4
Storage:
-20
UN-No:
Non-Hazardous - /

T-863 is a potent inhibitor of diacylglycerol acetyltransferase-1 (DGAT-1; IC50 = 15 nM).{45094} It is selective for DGAT-1 over DGAT-2 and acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1; IC50s = >10 and 12 μM, respectively). T-863 inhibits triacylglycerol synthesis in HuTu 80 cells (IC50 = 4 nM). In vivo, T-863 (20 mg/kg) reduces plasma triacylglycerol levels, the ratio of triacylglycerols to diacylglycerols, and body weight in a mouse model of diet-induced obesity.  

 

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SKU: 25807 - 25 mg Category:

Description

A DGAT-1 inhibitor (IC50 = 15 nM); selective for DGAT-1 over DGAT-2 and ACAT-1 (IC50s = >10 and 12 μM, respectively); inhibits triacylglycerol synthesis in HuTu 80 cells (IC50 = 4 nM); reduces plasma triacylglycerol levels, the ratio of triacylglycerols:diacylglycerols, and body weight in a mouse model of diet-induced obesity at 20 mg/kg

Formal name: trans-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid

Synonyms: 

Molecular weight: 394.5

CAS: 701232-20-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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