An internal standard for the quantification of edoxaban by GC- or LC-MS

Edoxaban-d6 – 500 µg

Brand:
Cayman
CAS:
1304701-57-2
Storage:
-20
UN-No:
Non-Hazardous - /

Edoxaban-d6 is intended for use as an internal standard for the quantification of edoxaban (Item No. 24030) by GC- or LC-MS. Edoxaban is an orally bioavailable and potent inhibitor of factor Xa (Kis = 0.561 and 0.903 nM for free and complexed human factor Xa, respectively).{41299} It is >10,000-fold selective for factor Xa over thrombin, FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin, and chymotrypsin. Edoxaban prolongs prothrombin, activated partial thromboplastin, and thrombin clotting times in a concentration-dependent manner ex vivo in human plasma. Oral administration of edoxaban (0.5-12.5 mg/kg) reduces thrombus formation and prolongs prothrombin time in a dose-dependent manner in rat and rabbit models of venous stasis thrombosis. It also reduces thrombus formation in a rat model of platinum wire-induced venous thrombosis. Formulations containing edoxaban have been used to prevent stroke in patients with atrial fibrillation.  

 

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SKU: 25760 - 500 µg Category:

Description

An internal standard for the quantification of edoxaban by GC- or LC-MS

Formal name: N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[[di(methyl-d3)amino]carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-ethanediamide

Synonyms: 

Molecular weight: 554.1

CAS: 1304701-57-2

Purity: ≥99% deuterated forms (d1-d6)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cardiovascular System|Heart|Arrhythmia

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