A non-selective monovalent cation ionophore; has low antimicrobial activity; induces swelling of rat liver mitochondria

Monactin – 1 mg

Brand:
Cayman
CAS:
7182-54-9
Storage:
-20
UN-No:
Non-Hazardous - /

Monactin is a mactrotetralide antibiotic originally isolated from Streptomyces and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium.{43436,43437} It has low antimicrobial activity but is more active than its homolog nonactin (Item No. 19468).{43438,43439} Monactin induces swelling of rat liver mitochondria in medium containing either potassium or sodium, stimulates respiration, and uncouples oxidative phosphorylation.{43440} It also inhibits Wnt signaling via inhibition of TCF-β-catenin transcriptional activity.{43441}  

 

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SKU: 25742 - 1 mg Category:

Description

A non-selective monovalent cation ionophore; has low antimicrobial activity; induces swelling of rat liver mitochondria, stimulates respiration, and uncouples oxidative phosphorylation; inhibits Wnt signaling via inhibition of TCF-β-catenin transcriptional activity

Formal name: (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-5-ethyl-2,11,14,20,23,29,32-heptamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone

Synonyms: 

Molecular weight: 751

CAS: 7182-54-9

Purity: ≥95%

Formulation: A film

Product Type|Biochemicals|Antibiotics|Ionophores||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease

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