An internal standard for the quantification of glyburide by GC- or LC-MS

Glyburide-d3 – 1 mg

Brand:
Cayman
CAS:
1219803-02-7
Storage:
-20
UN-No:
Non-Hazardous - /

Glyburide-d3 is intended for use as an internal standard for the quantification of glyburide (Item No. 15009) by GC- or LC-MS. Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM).{22674} It binds to microsomes derived from RINm5F pancreatic β-cells (Kd = 0.3 nM) and inhibits 86Rb+ efflux from intact RINm5 cells with a half-maximal inhibition (K0.5) value of 0.06 nM.{22672} Glyburide (5 mg/kg) reduces blood glucose levels and increases the activity of hepatic glutathione-S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{43282} It inhibits ATP-induced increases in caspase-1 activation and IL-1β and IL-18 secretion in a concentration-dependent manner in LPS-primed bone marrow-derived macrophages (BMDMs).{22671} Glyburide (80 mg/ml) also reduces lesion growth in mice infected with L. mexicana.{22673} Formulations containing glyburide have been used in the treatment of type 2 diabetes.  

 

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Description

An internal standard for the quantification of glyburide by GC- or LC-MS

Formal name: 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-(methoxy-d3)-benzamide

Synonyms:  Glibenclamide-d3

Molecular weight: 497

CAS: 1219803-02-7

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases|Leprosy||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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