A stilbene polyphenol with diverse biological activities; induces disaggregation of aggregated Aβ42 fibrils in a cell-free assay and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures; reduces production of ROS

trans-ε-Viniferin – 500 µg

Brand:
Cayman
CAS:
62218-08-0
Storage:
-20
UN-No:
Non-Hazardous - /

trans-ε-Viniferin is a stilbene polyphenol and dimer of trans-resveratrol (Item No. 70675) that has been found in various red wines and has diverse biological activities.{47517,47518,47519,47520,47521} It induces disaggregation of aggregated amyloid-β (1-42) (Aβ42; Item No. 20574) fibrils in a cell-free assay and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures.{47518} trans-ε-Viniferin reduces cytotoxicity induced by truncated huntingtin (Htt) in PC12 cells (EC50 = 30 nM).{47519} It also reduces production of reactive oxygen species (ROS), mitochondrial dysfunction, and PGC-1α depletion and increases protein levels and deacetylase activity of sirtuin 3 (SIRT3) in cells expressing mutant Htt. trans-ε-Viniferin inhibits calcium-activated chloride channel currents in HT-29 cells (IC50 = ~1 μM).{47520} In vivo, trans-ε-viniferin (2 μg per animal) reduces rotavirus-induced secretory diarrhea in mice without affecting the rotaviral infection. Dietary administration of trans-ε-viniferin reduces hepatic triglyceride accumulation and body weight increases in a mouse model of diet-induced obesity.{47521}  

 

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SKU: 25737 - 500 µg Category:

Description

A stilbene polyphenol with diverse biological activities; induces disaggregation of aggregated Aβ42 fibrils in a cell-free assay and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures; reduces production of ROS, mitochondrial dysfunction, and PGC-1α depletion and increases protein levels and deacetylase activity of SIRT3 in cells expressing mutant Htt; inhibits calcium-activated chloride channel currents in HT-29 cells (IC50 = ~1 μM); reduces rotavirus-induced secretory diarrhea in mice at 2 μg per animal; reduces hepatic triglyceride accumulation and body weight increases in a mouse model of diet-induced obesity

Formal name: 5-[(2R,3R)-2,3-dihydro-6-hydroxy-2-(4-hydroxyphenyl)-4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-3-benzofuranyl]-1,3-benzenediol

Synonyms:  (–)-ε-Viniferin

Molecular weight: 454.5

CAS: 62218-08-0

Purity: ≥90%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Natural Products|Stilbenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation||Research Area|Infectious Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease

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