An internal standard for the quantification of ivabradine by GC- or LC-MS

Ivabradine-d3 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
1217809-61-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Ivabradine-d3 is intended for use as an internal standard for the quantification of ivabradine (Item No. 15868) by GC- or LC-MS. Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that blocks the mixed sodium/potassium inward funny current (If) in HEK293 cells expressing mouse HCN1, human HCN2, and human HCN4 (EC50s = 4.5, 4.52, and 4.28 μM, respectively).{25789} In vivo, ivabradine (10 mg/kg per day) reduces heart rate, incidence of ventricular tachycardia and ventricular fibrillation, and arrhythmic mortality in a rat model of myocardial infarction.{37776} Formulations containing ivabradine have been used in the treatment of heart failure and angina.  

 

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SKU: 25711 - 1 mg Category:

Description

An internal standard for the quantification of ivabradine by GC- or LC-MS

Formal name: (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl-d3)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one, monohydrochloride

Synonyms: 

Molecular weight: 508.1

CAS: 1217809-61-4

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Research Area|Cardiovascular System|Cardiovascular Diseases|Angina||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Arrhythmia

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