An aconitine-type diterpenoid alkaloid that has been found in Aconitum species; increases protein levels of the efflux transporters P-glycoprotein

Benzoylaconine – 5 mg

Brand:
Cayman
CAS:
466-24-0
Storage:
-20
UN-No:
Non-Hazardous - /

Benzoylaconine is an aconitine-type diterpenoid alkaloid that has been found in Aconitum species.{42485,42486} Benzoylaconine increases protein levels of the efflux transporters P-glycoprotein, multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in LS174T cells in a concentration-dependent manner.{42486,42487} It also increases the protein levels of P-glycoprotein in Caco-2 cells and the pregnane X receptor (PXR) in both Caco-2 and LS174T cells when used at a concentration of 50 μM.{42487} Benzoylaconine (50 μM) reduces the cytotoxic effects of the P-glycoprotein substrates vincristine (Item No. 11764) and doxorubicin (Item No. 15007) in Caco-2 cells. In vivo, benzoylaconine (0.6 mg/kg) increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice.{42486} It also increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.).{42485}  

 

Available on backorder

Add to quotes
SKU: 25687 - 5 mg Category:

Description

An aconitine-type diterpenoid alkaloid that has been found in Aconitum species; increases protein levels of the efflux transporters P-glycoprotein, MRP2, and BCRP in LS174T cells in a concentration-dependent manner; increases the protein levels of P-glycoprotein in Caco-2 cells and the PXR in both Caco-2 and LS174T cells at 50 μM; reduces the cytotoxic effects of the P-glycoprotein substrates vincristine and doxorubicin in Caco-2 cells at 50 μM; increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice at 0.6 mg/kg; increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.)

Formal name: (1α,3α,6α,14α,15α,16β)-20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane-3,8,13,14,15-pentol, 14-benzoate

Synonyms: 

Molecular weight: 603.7

CAS: 466-24-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Multidrug Resistance||Research Area|Neuroscience||Research Area|Toxicology|Drug Metabolism

Related products

  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 500 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 500 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 1 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 1 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 10 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 25 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 25 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page