An aconitine-type diterpenoid alkaloid that has been found in Aconitum species; increases protein levels of the efflux transporters P-glycoprotein

Benzoylaconine – 10 mg

Brand:
Cayman
CAS:
466-24-0
Storage:
-20
UN-No:
Non-Hazardous - /

Benzoylaconine is an aconitine-type diterpenoid alkaloid that has been found in Aconitum species.{42485,42486} Benzoylaconine increases protein levels of the efflux transporters P-glycoprotein, multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in LS174T cells in a concentration-dependent manner.{42486,42487} It also increases the protein levels of P-glycoprotein in Caco-2 cells and the pregnane X receptor (PXR) in both Caco-2 and LS174T cells when used at a concentration of 50 μM.{42487} Benzoylaconine (50 μM) reduces the cytotoxic effects of the P-glycoprotein substrates vincristine (Item No. 11764) and doxorubicin (Item No. 15007) in Caco-2 cells. In vivo, benzoylaconine (0.6 mg/kg) increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice.{42486} It also increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.).{42485}  

 

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Description

An aconitine-type diterpenoid alkaloid that has been found in Aconitum species; increases protein levels of the efflux transporters P-glycoprotein, MRP2, and BCRP in LS174T cells in a concentration-dependent manner; increases the protein levels of P-glycoprotein in Caco-2 cells and the PXR in both Caco-2 and LS174T cells at 50 μM; reduces the cytotoxic effects of the P-glycoprotein substrates vincristine and doxorubicin in Caco-2 cells at 50 μM; increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice at 0.6 mg/kg; increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.)

Formal name: (1α,3α,6α,14α,15α,16β)-20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane-3,8,13,14,15-pentol, 14-benzoate

Synonyms: 

Molecular weight: 603.7

CAS: 466-24-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Multidrug Resistance||Research Area|Neuroscience||Research Area|Toxicology|Drug Metabolism

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