A diterpenoid with anti-inflammatory and anticancer properties; an inhibitor of AKT1 and AKT2 (IC50s = 8.4 and 8.9 µM

Oridonin – 10 mg

Brand:
Cayman
CAS:
28957-04-2
Storage:
-20
UN-No:
Non-Hazardous - /

Oridonin is a diterpenoid that has been found in R. rubescens and has anti-inflammatory and anticancer properties.{42522,42523} It is an inhibitor of AKT1 and AKT2 (IC50s = 8.4 and 8.9 µM, respectively).{42522} Oridonin inhibits proliferation of KYSE70, KYSE410, and KYSE450 esophageal cancer cells in a dose-dependent manner, halts the cell cycle at the G2/M phase, and induces apoptosis when used at a concentration of 20 µM. It decreases the expression of cleaved poly(ADP-ribose) polymerase (PARP), caspase-3, caspase-7, and Bims and the protein levels of phosphorylated AKT and reduces AKT activity. Oridonin reduces tumor growth in patient-derived mouse tumor models when administered at doses of 40 and 160 mg/kg. Oridonin is also an inhibitor of NLRP3 inflammasome assembly and activation.{42523} It inhibits inflammation in wild-type, but not Nlrp3-/-, mice in a model of high-fat diet-induced type 2 diabetes when administered at a dose of 3 mg/kg.  

 

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SKU: 25665 - 10 mg Category:

Description

A diterpenoid with anti-inflammatory and anticancer properties; an inhibitor of AKT1 and AKT2 (IC50s = 8.4 and 8.9 µM, respectively); inhibits proliferation of KYSE70, KYSE410, and KYSE450 esophageal cancer cells, halts the cell cycle at the G2/M phase, and induces apoptosis at 20 µM; decreases the protein levels of phosphorylated AKT and reduces AKT activity; reduces tumor growth in patient-derived mouse tumor models at 40 and 160 mg/kg; an inhibitor of NLRP3 inflammasome assembly and activation; inhibits inflammation in wild-type, but not Nlrp3-/-, mice in a model of high-fat diet-induced type 2 diabetes at 3 mg/kg

Formal name: 7,20-epoxy-1α,6β,7α,14R-tetrahydroxy-kaur-16-en-15-one

Synonyms:  NSC 250682

Molecular weight: 364.4

CAS: 28957-04-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Immunology & Inflammation

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