A glucokinase activator (EC50s = 0.24 and 0.065 µM at low (2.5 mM) and high (10 mM) concentrations of glucose

MK-0941 – 10 mg

Brand:
Cayman
CAS:
1137916-97-2
Storage:
-20
UN-No:
Non-Hazardous - /

MK-0941 is a glucokinase activator with EC50 values of 0.24 and 0.065 µM at low (2.5 mM) and high (10 mM) concentrations of glucose, respectively.{37711} It increases insulin secretion from isolated rat islets of Langerhans and glucose uptake by hepatocytes in vitro. MK-0941 reduces blood glucose levels in high-fat diet-fed db/db mice and in high-fat diet-fed mice with diabetes induced by streptozotocin (Item No. 13104).  

 

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SKU: 25642 - 10 mg Category:

Description

A glucokinase activator (EC50s = 0.24 and 0.065 µM at low (2.5 mM) and high (10 mM) concentrations of glucose, respectively); increases insulin secretion from isolated rat islets of Langerhans and glucose uptake by hepatocytes in vitro

Formal name: 3-[[6-(ethylsulfonyl)-3-pyridinyl]oxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)-benzamide, monomethanesulfonate

Synonyms: 

Molecular weight: 556.6

CAS: 1137916-97-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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